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A Meta-Analysis of the Efficacy of Pomalidomide-Based Regimens for the Treatment of Relapsed/Refractory Multiple Myeloma After Lenalidomide Exposure
CONCLUSION: Pomalidomide-based combination regimens were effective in patients with RRMM previously treated with lenalidomide and tended to be associated with better outcomes when used earlier in the treatment pathway. A drug class switch may not always be necessary when making treatment decisions for patients with RRMM for whom the benefits of lenalidomide have been exhausted, although this must be supported by comparative studies.PMID:37684184 | DOI:10.1016/j.clml.2023.07.010
Source: Clinical Lymphoma and Myeloma - September 8, 2023 Category: Cancer & Oncology Authors: Faith E Davies Xavier Leleu Prisca Vogel Sujith Dhanasiri Pauline Le Nouveau Katja Weisel Source Type: research

Computer-aided search for 5-arylideneimidazolone anticancer agents able to overcome ABCB1-based multidrug resistance
ChemMedChem. 2021 Apr 30. doi: 10.1002/cmdc.202100252. Online ahead of print.ABSTRACTABCB1 modulation is an interesting strategy in search for new anticancer agents overcoming multidrug resistance (MDR). Hence, 17 new 5-arylideneimidazolones containing amine moiety, as potential ABCB1 inhibitors was designed, synthesized, and investigated. The series was tested in both, parental (PAR) and multidrug resistant (MDR) overproducing ABCB1, T-lymphoma cancer cells using cytotoxicity assay. The ABCB1 modulating activity was examined in the rhodamine 123 accumulation test, followed by Pgp-Glo™ Assay to determine an influence of ...
Source: ChemMedChem - April 30, 2021 Category: Chemistry Authors: Aneta Kaczor Nikoletta Szemer édi Katarzyna Kucwaj-Brysz Monika D ąbrowska Ma łgorzata Starek Gniewomir Latacz Gabriella Spengler Jadwiga Handzlik Source Type: research

Maternal and perinatal outcomes following a diagnosis of Hodgkin lymphoma during or prior to pregnancy: a systematic review
CONCLUSIONS: Rates of most adverse pregnancy outcomes among women with a previous/current HL diagnosis are not increased significantly compared to the general pregnant population. Women with HL during pregnancy may have a higher PTB rate and increased likelihood of VTE, anaemia and blood transfusion, however small study numbers and low-very low GRADE certainty of findings preclude conclusions.PMID:36424902 | DOI:10.1111/1471-0528.17347
Source: BJOG : An International Journal of Obstetrics and Gynaecology - November 25, 2022 Category: OBGYN Authors: Orla A Houlihan Daire Buckley Gillian M Maher Fergus P McCarthy Ali S Khashan Source Type: research

Yoga in addition to standard care for patients with haematological malignancies.
CONCLUSIONS: The currently available data provide little information about the effectiveness of yoga interventions for people suffering from haematological malignancies. The finding that yoga may be beneficial for the patients' quality of sleep is based on a very small body of evidence. Therefore, the role of yoga as an additional therapy for haematological malignancies remains unclear. Further high-quality randomised controlled trials with larger numbers of participants are needed to make a definitive statement. PMID: 24919720 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 12, 2014 Category: Journals (General) Authors: Felbel S, Meerpohl JJ, Monsef I, Engert A, Skoetz N Tags: Cochrane Database Syst Rev Source Type: research

Question 2: Does the timing of central line placement in relationship to the initiation of acute lymphoblastic leukaemia therapy change the risk of thrombosis or infection?
Question Does the timing of central line placement in relationship to the initiation of acute lymphoblastic leukaemia (ALL) therapy change the risk of thrombosis or infection? Clinical scenario You are the haematology registrar doing ward rounds with your consultant. A 3-year-old with newly diagnosed ALL is expected to start induction chemotherapy in a few days. Your consultant questions if we should consult surgery for line placement prior to induction chemotherapy or if we should wait until remission is achieved. Structured question In children with ALL (population), does placing a central line at the end of induction (i...
Source: Archives of Disease in Childhood - December 15, 2014 Category: Pediatrics Authors: Frediani, J. N., Phillips, B. Tags: ADC Archimedes, Oncology, Immunology (including allergy), Reproductive medicine Source Type: research

CD177 Expression on Neutrophils: In Search of a Clonal Assay for Myeloid Neoplasia by Flow Cytometry.
Conclusions: Skewed low neutrophil CD177(%) is highly associated with clonal myeloid disorders, particularly myelodysplasia, and may be useful for detecting clonal myeloid disorders. PMID: 24124144 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - October 15, 2013 Category: Pathology Authors: Meyerson HJ, Osei E, Schweitzer K, Blidaru G, Edinger A, Balog A Tags: Am J Clin Pathol Source Type: research

The Search for Surrogate Endpoints in Trials in Diffuse Large B-Cell Lymphoma: The Surrogate Endpoints for Aggressive Lymphoma Project.
PMID: 28798271 [PubMed - as supplied by publisher]
Source: The Oncologist - August 10, 2017 Category: Cancer & Oncology Authors: Sargent DJ, Shi Q, Flowers CR, Schmitz N, Habermann TM, Flament J, Fu T, Coiffier B, SEAL group Tags: Oncologist Source Type: research

Adjuvant gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in premenopausal women.
CONCLUSIONS: GnRH agonist appears to be effective in protecting the ovaries during chemotherapy, in terms of maintenance and resumption of menstruation, treatment-related premature ovarian failure and ovulation. Evidence for protection of fertility was insufficient and needs further investigation. Evidence was also insufficient to assess the effect of GnRH agonist and GnRH antagonist cotreatment on ovarian protection against chemotherapy. The included studies differed in some important aspects of design, and most of these studies had no age-determined subgroup analysis. Large and well-designed RCTs with longer follow-up du...
Source: Cochrane Database of Systematic Reviews - March 2, 2019 Category: General Medicine Authors: Chen H, Xiao L, Li J, Cui L, Huang W Tags: Cochrane Database Syst Rev Source Type: research

Molecules, Vol. 25, Pages 2258: Search for ABCB1 Modulators Among 2-Amine-5-arylideneimidazolones As a New Perspective to Overcome Cancer Multidrug Resistance
a Handzlik Multidrug resistance (MDR) is a severe problem in the treatment of cancer with overexpression of glycoprotein P (Pgp, ABCB1) as a reason for chemotherapy failure. A series of 14 novel 5-arylideneimidazolone derivatives containing the morpholine moiety, with respect to two different topologies (groups A and B), were designed and obtained in a three- or four-step synthesis, involving the Dimroth rearrangement. The new compounds were tested for their inhibition of the ABCB1 efflux pump in both sensitive (parental (PAR)) and ABCB1-overexpressing (MDR) T-lymphoma cancer cells in a rhodamine 123 accumulation assay...
Source: Molecules - May 10, 2020 Category: Chemistry Authors: Aneta Kaczor M árta Nové Annam ária Kincses Gabriella Spengler Ewa Szyma ńska Gniewomir Latacz Jadwiga Handzlik Tags: Article Source Type: research

Pulmonary arterial hypertension in a patient with multiple myeloma during carfilzomib treatment: in search of better management.
CONCLUSION: The mechanism responsible for cardiac and vascular events during carfilzomib therapy is unclear. This case report highlights that it is important to define at baseline the appropriate screening of patients undergoing carfilzomib therapy with specific monitoring and symptom management and that future large prospective controlled studies are needed to define the correct monitoring strategy in refractory and relapsed multiple myeloma and the potential mechanism of vascular events. PMID: 33525991 [PubMed - as supplied by publisher]
Source: Tumori - February 4, 2021 Category: Cancer & Oncology Tags: Tumori Source Type: research

IJERPH, Vol. 18, Pages 4008: Development of a Questionnaire for the Search for Occupational Causes in Patients with Non-Hodgkin Lymphoma: The RHELYPRO Study
In conclusion, this questionnaire appears as a useful tool to identify NHL patients for a specialized consultation, in order to ask for compensation for occupational disease.
Source: International Journal of Environmental Research and Public Health - April 11, 2021 Category: Environmental Health Authors: Mireille Matrat Murielle Gain Corinne Haioun Fabien Le Bras Catherine Nisse Franck Morschhauser B énédicte Clin Isabelle Baldi Catherine Verdun-Esquer Robert Garnier Herv é Laborde-Castérot Fabrice H érin Yolande Esquirol Pascal Andujar Milia Belacel Tags: Article Source Type: research

Development of a Questionnaire for the Search for Occupational Causes in Patients with Non-Hodgkin Lymphoma: The RHELYPRO Study
In conclusion, this questionnaire appears as a useful tool to identify NHL patients for a specialized consultation, in order to ask for compensation for occupational disease.PMID:33920383 | DOI:10.3390/ijerph18084008
Source: Clinical Lymphoma and Myeloma - April 30, 2021 Category: Cancer & Oncology Authors: Mireille Matrat Murielle Gain Corinne Haioun Fabien Le Bras Catherine Nisse Franck Morschhauser B énédicte Clin Isabelle Baldi Catherine Verdun-Esquer Robert Garnier Herv é Laborde-Castérot Fabrice H érin Yolande Esquirol Pascal Andujar Milia Belacel Source Type: research